Here's an excerpt from Chapter 8 The High Cost of Inactivity
"Chair time was a strong risk factor for dying of a heart-related event and for many forms of cancer as well. Women who sat more than 6 hours a day had an especially high risk of death as compared to those who spent half time sitting."
"A research group at the University of Missouri found that in addition to deconditioning your body (if you don't use it, you lose it) sitting alters the way the body metabolizes fat. Among other things, it shuts off lipase. a pancreatic enzyme that is key for the absorption of fat into muscles. Lipase deficiency allows fat to build up in the bloodstream. This can result in elevated levels of bad LDL cholesterol and triglycerides, excess belly fat, and , ultimately, prediabetes, diabetes, and heart disease."